A victor of five consecutive fights, including two title defenses, Miocic has run through numerous top contenders at heavyweight, but now he'll be facing one of the best prospects to join the roster in several years.
At Sportsbet, Ngannou is paying $1.62, with Miocic at $2.31.
With Stipe Miocic (17-2) looking at a record setting third straight title defense, there's no question UFC 220 will be big.
This would mark just the fourth time in UFC history that the heavyweight and light heavyweight titles would be at stake on the same card.
The Ohio native then avenged his last loss, to Junior dos Santos, stopping the Brazilian in a little over two minutes at UFC 221 in Dallas. All 26 of his strikes were considered significant, according to FightMetric.
After dos Santos fell to the canvas, Miocic swarmed the former champion and threw more than a dozen left-handed punches through the guard, and when those strikes went unanswered, referee Herb Dean called a stop to the bout.
Miocic has not fought since that May encounter, unable to come to an agreement on a contract renegotiation with the UFC.
As for Ngannou, he has yet to be beaten under the UFC banner. Both he and Miocic have finished their past four opponents in the first round.