As allegations against disgraced Hollywood executive Harvey Weinstein pile up, more and more celebrities are coming forward to either confirm or deny their own pre-existing knowledge about the situation.
The "Family Guy" creator applauded Barth and the other women who spoke out about their alleged experiences with Weinstein.
After reading off a list of five women nominated in the Best Supporting Actress category, MacFarlane joked: "Congratulations, you five ladies no longer have to pretend to be attracted to Harvey Weinstein".
MacFarlane took some heat on social media after issuing his statement Wednesday, with critics contending the 2013 comment proves he was aware of Weinstein's behavior but - aside from making the televised jab - did nothing else to stop it.
MacFarlane explained that his friend and "Ted" colleague Jessica Barth had told him about a problematic encounter with the producer, so he chose to "take a hard swing" at Weinstein that "came from a place of loathing and anger".
Barth was one of the women to come forward with allegations against Weinstein in The New Yorker's bombshell story published Tuesday.
MacFarlane revealed today that what he said wasn't a joke and that he knew about Weinstein.
He added: 'Make no mistake, this came from a place of loathing and anger'. "There is nothing more abhorrent and indefensible than abuse of power such as this". And when it comes to someone who is influential in the industry you work in (Hollywood or otherwise) you could be at risk of being blackballed and would never be able to work again.
Barth quickly came to MacFarlane's defense, saying MacFarlane was "respecting my wishes" by not confronting Weinstein.
The 65-year-old movie mogul is facing a number of sexual assault allegations which have emerged over three decades, with actresses Angelina Jolie, Gwyneth Paltrow, Ashley Judd and Rose McGowan among the accusers.
Weinstein responded to the report in a lengthy, rambling statement in which he pleaded for a second chance and apologized for the pain he had caused. McGowan claimed that Affleck knew years ago because she told him about Weinstein and said Affleck told her, "Goddamnit!"