Arsenal defender Shkodran Mustafi has been ruled out of action for up to six weeks after sustaining a thigh injury on global duty.
"I don't think he will be available before the next global break".
If both defenders are unavailable, Wenger will have to turn to back-up options Per Mertesacker and Rob Holding to fill the void, as Calum Chambers also remains sidelined with a hip injury.
Arsenal will resume Premier League action this weekend with a trip to Watford on the back of an unbeaten run through seven outings in all competitions, with four successive victories.
Nevertheless, Arsene Wenger is ready to call upon the Frenchman for this weekend's visit to Watford with Mustafi certain to miss out.
Wenger explained: "Koscielny has a definite final test tomorrow". But he trained on his own and the first signs are positive.
"Watford are a strong side, well balanced and a tough opposition for everybody. If he has no pain on his Achilles then he will play".
It was in Belarus where Wilshere showed shades of the form that saw him regarded as one of England's brightest young players when he first broke through at The Emirates.
Arsenal, though, could be boosted by the return of playmaker Mesut Ozil from a knee injury and also England forward Danny Welbeck, who has now resumed full training after a groin problem sustained during the goalless draw at Chelsea on September 17.
"The minor problem we have is with Sead Kolasinac".
Alexis Sanchez will be assessed when he returns from global duty after he received "special treatment" following Chile's 3-0 defeat to Brazil.