He joins midfielder N'Golo Kante on the sidelines, but Blues manager Conte is hopeful top scorer Alvaro Morata will be fit to return after sitting out the Palace game with a hamstring problem.
Which key battles could be decisive in the outcome at Stamford Bridge, then?
Chelsea's players have usually been granted a day off after a match during Conte's time in charge, but were pictured training at Cobham on Sunday following their lacklustre performance against Palace.
Chelsea have endured a frustrating couple of weeks with a number of injury blows coinciding with two straight Premier League defeats. For this reason we have to put 150% in; 100% won't be enough. A defeat is always a defeat... this season will be very hard for us.
"Now it's a little sticky moment but we need to come through that together and we have a chance to respond on Wednesday".
The former Juventus coach said the current season will be more hard as unlike last season, the Chelsea players will have to cope with the extra physical and mental burden of competing in domestic tournaments as well as the Champions League.
Gary Cahill urged Chelsea to go on the kind of relentless winning run that resulted in them taking control of the title race after a slow start last season.
"I didn't see this [reaction]", Conte added.
"I think the performance of the whole team was bad, not one player or two players, but all the players today".
"It is normal to be angry after a bad performance, but every player had a bad performance".