With Real Madrid, the two-time defending champions, and Apoel Nicosia, the Cypriot minnows, making up group H, Dortmund are widely expected to be Tottenham's most direct competitors for qualification.
Borussia Dortmund may be going through a hard period with injuries, presenting continually challenges for new manager Peter Bosz, but there's also some optimism ahead of the Tottenham Hotspur match. It will be tough because Dortmund is a great, great team, but our mentality is to try to win and be aggressive from the first ball.
Wins Tottenham managed in three Champions League group matches at Wembley last season.
Spurs are playing all their home games at Wembley this season, as they prepare to move into a new ground next year.
However, Owen - who played 30 times in the Champions League for Liverpool, Man Utd and Los Blancos - wrote on Betvictor that Spurs are due some good form at the national stadium. "In the last few games we've played at Wembley, we've played well and deserved more". The Premier League is the principal competition for every player that plays in the Premier League. "Now, it is important for Tottenham's season to get their first win at Wembley", he added.
Tottenham, who host Dortmund at Wembley on Wednesday, faced the German side in the Europa League two seasons ago and were beaten 5-1 on aggregate in the last 16.
However, the 35-year-old midfielder did say that the current Spurs team does have the potential to perform and succeed at any level. "But fortunately we have a fantastic squad and I'm sure whoever comes in will be ready to compete on the big stage", Kane said.
"With Wembley, we need to adapt our game", said boss Mauricio Pochettino.
"Last year we got off to a bad start".
"We were very focused on trying to win the Premier League and fighting with (eventual champions) Leicester".