"I'm glad because it's what we want from the players, that when they play, they try to do it well, and he did so".
And while Real have endured a rough start to their title defence, Alaves are suffering a nightmare start to the season themselves as they have lost all five matches so far and already sacked coach Luis Zubeldia.
Atletico's unbeaten start to the season will be severely tested over the next week with Sevilla and Chelsea also visiting the Wanda Metropolitano.
Fourteen regional government officials were detained on Wednesday as part of the crackdown by the Spanish government on plans for the referendum.
Karim Benzema is now signed with Real Madrid until June 30, 2021.
Setien kept four of his best attackers on the bench, introducing three as the game wore on.
The 29-year-old began his career with Lyon's reserve team back in 2004, first starting as a ball boy during Lyon's senior club games and working his way up.
He added of the Betis loss, where Antonio Sanabria struck a stoppage-time victor: "We had 27 chances and the ball didn't want to go in". All those seven points have been dropped at home and not since 1995/96 have Madrid failed to win in any of their first three home league games.
"We did not have a great game but neither a bad game".
Zidane senior said: "Hopefully he doesn't score, because we're competitive". This is long, we have 33 games left to play'. "It's going to be a very special match, something rare but that's a good thing".
Elsewhere, Leganes drew 0-0 with Girona and Deportivo beat Alaves 1-0.
Sanabria had an effort disallowed for offside in the final minute of normal time, but rose highest to head in a 94th-minute victor to secure a memorable backs-to-the-wall victory for Quique Setien's side.