The health status of Paul Pogba, who reigned as the world's most expensive player from last summer until the Neymar deal was struck this past summer, is very much in question.
Mourinho has continually dodged questions regarding Pogba's future availability - presumably to ensure any setback in his recovery is not noticed - and his stance remains no different as United prepare to travel to St Mary's.
According to a report in ESPN , United will be making a decision before September 30, and decide on the best course of action.
The report also added that the club has been in touch with Finnish muscle fix specialist Sakari Orava, with a decision set to be made about the necessity of a surgery. Dembele suffered a ruptured tendon, which is more serious than the muscle tear Pogba is now working his way back from.
"So I'm not going to cry or count the days for Pogba to return".
Mourinho claimed he will have to rely on his squad, and that's not something he will be too anxious about doing, with the middle of the park having particular strength in depth.
Jose Mourinho admitted that he was unsure of a timeline for Pogba's return, claiming he was unsure whether he'd be out for "12 weeks or 12 days".
"I see a great improvement in the person, in the mood, in the face, in the body language - if you want just a word, in the happiness", Mourinho added. "Until he's back, I trust my players".