It's still possible that he will only miss a few weeks, should the injury not require surgery, and that determination will come over the next few days, according to ESPN's Adam Schefter.
"He wants to find a way to play", Arians said of Johnson, via Arizona Sports 98.7. Last season, David Johnson led the National Football League in yards from scrimmage and touchdowns. He had 80 receptions for 879 yards and four touchdowns last season.
From GMFB: The #AZCardinals await MRI results on star RB David Johnson, who sprained his wrist yesterday. While McCoy rumbled to 110 rushing yards and 49 receiving yards on 27 total touches, Tolbert received 13 touches, tallying 54 yards and a touchdown in the Bills opener. "When Danny's on a roll, he's a big factor for us, but he took an injury today", Ravens running back Terrance West said. Andre Ellington is worth a look too in deeper formats in case the Cardinals employ an RBBC in Johnson's absence. The team should know the full extent of the injury on Tuesday. Placement on IR would cost him at least eight weeks, at which point he could return to action if the Cardinals keep that option open for him.
The 25-year-old Johnson appeared to get injured while making a 24-yard reception in the third quarter.
Johnson clearly favored the wrist after the fumble and did not really use his left wrist to help himself get up.
La Canfora added that Johnson will be brought in to add backfield depth following the wrist injury suffered by starter David Johnson in Week 1. He averaged just 3.8 yards per carry last season and did not have a run longer than 18 yards.