Here are a few players to watch from both teams.
With all due respect to Petr Cech, Schmeichel is the greatest goalkeeper of the Premier League era, a man nearly as important as Eric Cantona.
Ederson added that the opportunity to work under Guardiola played a significant role in persuading him to sign for Manchester City.
Newcastle United was promoted to the EPL secondly after defeating Preston North End 4-1 at home on April 24, 2017, while Huddersfield Town was also promoted to the Premier League after smashing Reading 4-3 on penalties after a 0-0 draw in both regular and extra time in the EFL Championship play-off final on May 29, 2017. Will Jurgen Klopp lead Liverpool to their first Premier League title in the modern area or will Mauricio Pochettino finally take Spurs one step further?
Jose Mourinho has provided an update on the possibility of Zlatan Ibrahimovic rejoining Manchester United just two months after the forward was released by the club. Éderson will make his PL debut after City signed him from Benfica as the most expensive goalkeeper in history. He even won the Ballon d'Or.
Since Ferguson's departure, United have finished seventh, fourth, fifth and sixth in the Premier League.
"My family and I were fortunate enough to travel across seven states, driving over 2,000 miles, following Manchester City on tour (in America) this summer and we had the most fantastic time". Is he be the new Thierry Henry?
Guardiola's reported desire to bring Alexis Sanchez to the Etihad Stadium and his previously reserved praise of Aguero means the Argentina star's future at City remains a matter of intrigue.
"We needed to do that this summer because it was one of the oldest teams in Europe, not just the Premier League". United will cough up £18m this year for the pleasure of being owned by them.
They eased to victories over teams like Real Madrid, Tottenham Hotspur and West Ham, losing only to Manchester United. But it is this defence that looks the most undecided at the moment.
After spending millions in the window, will the likes of Man United and Man City display nearly ideal football, or will they fail to meet their silverware aspirations this season?
Pitch designs have also been banned, though, with Premier League rules saying turf must now have the traditional horizontal marking.
This is, after all, what the majority thought this time previous year.
Unmatchable as a consistent goalscoring midfielder: 10 consecutive seasons with double figures of Premier League goals. Arrived as the British record signing in 1993 but then inspired United to the 1994 double, the 1996 double and best of all the 1999 treble.